Featured Publications

1. Walter, M. J., Kajiwara, N., Karanja, P., Castro, M., and Holtzman, M. J. IL-12 p40 production by barrier epithelial cells during airway inflammation. (2001) J. Exp. Med. 193:339-352. PMCID: PMC2195918 | View here

2. Walter, M. J., Morton, J.D., Kajiwara, N., Agapov, E., and Holtzman, M. J. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. (2002) J. Clin. Invest. 110:165-175.  PMCID: PMC151043 | View here

3. Tyner, J. W., Uchida, O., Kajiwara, N., Kim, E. Y., O’Sullivan, M.P., Walter, M. J., Schwendener, R. A, Cook, D. N., Danoff, T. M., and Holtzman, M. J. CCL5-CCR5 interaction provides anti-apoptotic signals for macrophage survival during viral infection. (2005) Nat. Med. 11:1180-1187. | View here

4. Tyner, J. W., Kim, E. Y., Ide, K., Pelletier, M. R., Roswit, W. T., Morton, J. D., Battaile, J. T., Patel, A. C., Patterson, G. A., Castro, M., Spoor, M. S., You, Y., Brody, S. L., and Holtzman, M. J. Blocking airway mucous cell metaplasia by inhibiting EGFR anti-apoptosis and IL-13 transdifferentiation signals. (2006) J. Clin. Invest. 116:309-321. | View here

5. Grayson, M. H., Cheung, D., Rohlfing, M. M., Kitchens, R., Spiegel, D. E., Tucker, J., Battaile, J., Alevy, Y., Yan, L., Agapov, E., Kim, E. Y., & Holtzman, M. J. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. (2007) J. Exp. Med. 204:2759-2769. | View here

6. Kim, E. Y., Battaile, J. T., Patel, A. C., You, Y., Agapov, E., Grayson, M. H., Benoit, L. A., Byers, D. E., Alevy, Y., Tucker, J., Swanson, S., Tidwell, R., Tyner, J. W., Morton, J. D., Castro, M., Polineni, D., Patterson, G. A., Schwendener, R. A., Allard, J. D., Peltz, G., & Holtzman, M. J. Persistent activation of an innate immune axis translates respiratory viral infection into chronic inflammatory lung disease. (2008) Nat. Med. 14:633-640. | View here

7. Alevy, Y. G., Patel, A. C., Romero, A. G., Patel, D. A., Tucker, J., Roswit, W. T, Miller, C. A., Heier, R., Byers, D. E., Brett, T. J., and Holtzman, M. J. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. (2012) J. Clin. Invest. 122:4555-4568. | View here

8. Byers, D. E., Alexander-Brett, J., Patel, A. C., Agapov, E., Dang-Vu, G., Jin, X., Wu, K., You, Y., Alevy, Y., Girard, J.-P., Stappenbeck, T. S., Patterson, G. A., Pierce, R. A., Brody, S. L., and Holtzman, M. J. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. (2013) J. Clin. Invest. 123:3967-3982. (Cover Article) | View here

9. Wu, K., Byers, D. E., Jin, X., Agapov, E., Alexander-Brett, J., Patel, A. C., Cella, M., Gilfilan, S., Colonna, M., Kober, D. L., Brett, T. J., and Holtzman, M. J. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. (2015) J. Exp. Med. 212:681-697. PMCID: PMC4419356 | View here

10. Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S. L., Lawson, T. G., Omattage, N. S., Brett, T. J., and Holtzman, M. J. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. (2015) Nat. Immunol. 16:1215-1227 (selected for journal cover).