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The Holtzman Lab studies the role of respiratory viruses in causing acute and chronic disease, focusing on antiviral immune responses as pathways for pathogenesis and targets for drug discovery. We apply a multidisciplinary and translational approach to study cellular and mouse models as well as human subjects.

We have shown that viral immunity depends on a special network of innate immune-response genes in host cells of the airway epithelial barrier, and we have focused on this network as a drug target for antiviral therapy. In particular, we have engineered the interferon-signaling pathway to better control viral replication and have applied this strategy to new and emergent viruses in cell and animal models.